He should carry some back up parts in the unlikely event something breaks or tears on the cpap. Distribution systems for medical equipment are handled differently in different countries and they are not always easy to figure out quickly. It's not a big deal to stick an extra tube or mask parts in the luggage.
As for total machine failure--It's unlikely his machine will fail, as new ones are dual voltage. However, he should get the list of distributors from the manufacturer for every country he's going to before leaving the States, including the phone numbers and email. That way he could get help immediately,
At least two of the biggest manufacturers are Europan-based multi-nationals.
He'll probably find it easiest to stay in just a few places and take day trips, rather than pulling up stakes every few days. With a few good home bases and some down time built in for rest and recuperation, it should be a good trip for him.
Food: my French husband and my sons were extremely fussy when younger but survived fine. One thing to note is the EU has stricter rules against added hormones and chemicals in the food supply than the US.