If you are going to Brussels by Eurostar it would be best to go Heathrow to Cardiff and then train to Conwy and then Conwy / Llandudno Junction to London Euston for the short transfer to St.Pancras for the Eurostar.
Note that all trains stop at Llandudno Junction - which is just over 1 mile east of Conwy. Avanti West Coast also have direct trains from Llandudno Junction to Euston. Also consider taking a look at the historic English city of Chester - which is near the Welsh border. If going back to London Euston, you may find it cheaper to book an advance ticket from Crewe rather than north Wales and then just match up a connection from north Wales/Chester.
If you just want to get quickly back to Brussels from N Wales, Ryan Air has cheap flights from Manchester Airport - which has direct trains from north Wales. However, these flights go to Charleroi Airport which is to the south of Brussels.