Just returned from a two week trip to Amsterdam, Brussels, and Paris. I took my RS 20" roll aboard, a RS Euro Flight Bag, and a PacSafe Venture.
The roll aboard weighted 18 lbs and had plenty of extra room using packing bags for the first time. The Flight Bag contained my CPAP, hose, mask, Marmot jacket, vest, and hat. I didn't weight it. The PacSafe contained my iPhone and two iPads (my wife's iPad Air and my iPad mini) along with Ankor battery pack and accessories plus all the documentation/tickets/etc. It was around 8 lbs (that Ankor 20,000 mAh battery pack was heavy).
We actually checked the roll on bags so we didn't have to schlep them around the airports. Getting from airports to hotels and vice versa was easy.
Plusses
The Ankor battery pack was a great idea and came in really handy since I took close to 350 photos on the iPad and used the GPS continuously.
Another hit was the Ulmon City 2 Go mapping software. I had the iPhone in airplane mode the whole two weeks but the software showed us where we were the whole time and I was able to navigate the twisty streets with no issues. I'll never carry paper maps again.
My Debit Card worked fine in every ATM I tried it in. Also my USAA Chip and Signature credit card worked in all Metro/Tram automated ticket machines and almost all railway automated ticket machines.
Another big plus was the RS travel clothes line. We did laundry almost every night and things dried overnight in spite of the near 100% humidity the whole time.
We also took and used a set of plastic utensils (knife, fork and spoon) for picnicking. We didn't do a lot of that but they were handy when we did.
Minuses
The travel wash cloths were never needed. All three hotels we stayed in had washcloths I'll leave them home next time.
Ditto on not needing the emergency sewing and medical kit - although we'll take it next time anyway.
I took a pair of jeans along with two pairs of nylon travel-style pants. It turned out I could have left one of the travel pants home since I never wore them.
Weather averaged in the high 60s and low 70s the whole time we were there and we only got drizzled on one night. All in all it was a great trip. Oh, and by the way - we saw lots of interesting things.