Instead of my usual medium and small packing cubes, on my recent Adriatic tour trip I used a few of the mesh bags that were gifted with last year's Sierra Club renewal. One medium and two small mesh pouches subbed for a medium and a small cube. I had my usual cords-and-plugs padded zip and a large folder.
Not much difference inside my junior-size eBags weekender, just perhaps a little more ease in conforming to the shape of whatever was going on in there when I wasn't looking.
If there was anything notable, I suppose it would be neatness/accessibility when putting the pouches away in the hotel dresser drawers -- cubes unzipped and laid in the drawers look a little more presentable? But I wasn't worried about passing inspection, ha.
Any pros or cons that you have noticed?