I have packed pills and supplements for two different trips, and done it two different ways, and here are my results: 5 years ago, I purchased the small plastic ziploc coin/bead bags (size 1 inch by 2 inches, found in the beading arts section of Walmart) and packed a day's worth of supplements in them; baby aspirin, vitamin D, calcium, vitamin B, Zyrtec. These 21 bag-lets were then stuffed into a sandwich-sized baggie, air squeezed out, and these were packed into my big suitcase. Every day, it was easy to just get a bag-let out, take it after breakfast, and done. Prescription pills were kept in their original containers, and I kept these in my carry-on.
Ha - this year, I thought I would skip doing that; I just took 5 snack-sized baggies of the supplements; so, 21 baby-aspirin in a baggie, 21 Vitamin D's in a baggie etc. Big Mistake! It was SUCH A HASSLE every morning to get each supplement out, control it in my hand while I did that 4 MORE TIMES- aargh - it really was worth it 5 years ago to PRE-BAG all the supplements into their handy little bag-lets. Just for the annoyance factor ALONE! Prescription meds I always keep in their containers, in my carry-on. Next trip, I'll have to dig out those little plastic bags again and pre-pack.