I would check out this one by Cotopaxi. It is 35L, carry-on size (20" length), weighs 3#7oz ( without optional accessories), is waterproof, and has a lot of thoughtful design features. I especially like the clamshell opening.
https://www.indiegogo.com/projects/the-ultimate-adventure-travel-pack-allpa-35l-backpack--2#/
Scroll down past the crowdfunding image ( they have reached their goal) to the "early-bird" prices ( for September delivery). Videos and tech information are below that.
I do not use a travel backpack because all of our trips involve hiking in mountain regions, and I need a good daypack and extra gear---boots, hiking poles, Goretex jacket and pants, etc. I cannot carry both that daypack and a regular travel backpack without looking like a goof. So it is roller bag ( checked due to the poles) and daypack for me. But I do really like this bag.