Hi there -
We've walked that stretch between Casal Rotondo and San Callisto and then beyond to Porta San Sebastiano and then Baths of Caracalla and some churches. The section you're looking at covering will be closer to 3+ miles, and there is a lot to look at along the way so I'd estimate it taking a fair amount of time. It did for us, anyway. My camera got a workout!
The park's website gives the distance between Tomb of Cecilia Metella and Casal Rotondo as 4.5 km (2.79 miles). You'll be adding the distance from San Callixtus/Callisto to Cecilia Metella (closed on Sundays) so that's what I'm basing my estimate on
https://www.parcoappiaantica.it/itinerari/la-via-appia/
If you haven't found it yet, here is a great printed guide - in English - of notable landmarks along the way and a bit about them. Don't use this for hours/entry fees of attractions along the way; pretty sure that info is out of date but the rest is useful.
https://www.parcoappiaantica.it/wp-content/uploads/2016/05/AppiaAntica_eng_2015.pdf
The ''worth" question is always tough but we were glad we'd visited the Maxentius complex. As the park lists it as closed on Mondays, I'm just not sure you can access the site even though it's free.
https://www.turismoroma.it/en/places/villa-maxentius
And honestly, there is not a ton of visitor services along the way. We used the facilities located in a small separate complex at San Callixtus (which we didn't visit) en route from the catacombs of San Sebastiano (which we did) and had an OK cappuccino from a vending machine there. HA! There are a couple coffee-cup icons on this map on the park's website - one near the visitor center near the church of Domine Quo Vadis, and another near Capo Bove - that indicate places for a cuppa joe.
https://www.parcoappiaantica.it/wp-content/uploads/2016/05/Guida_Turistica_ITA_2019.pdf
One between Capo Bove and Cecilia Metella is Caffe Appia Antica; Via Appia Antica, 175, Roma. Looks darn pleasant!
https://appiaanticacaffe.it/en/home-en/#!/services
https://www.tripadvisor.com/Restaurant_Review-g187791-d3604614-Reviews-Appia_Antica_Caffe-Rome_Lazio.html