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Train from Zurich to Venice

We are going to Zurich for 3 days prior to our Italy tour. We will be departing Zurich on Sunday, May 17 and checking into our hotel in Venice that same day. Any suggestions for the quickest, most direct way to get to Venice by train? Should reservations be made in advance? Is luggage allowed on the train?
Any input is appreciated.

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We flew into Zurich last year before heading to Venice but we stayed in Lake Lugano which is so much nicer than Zurich. The train from Zurich to Lake Lugan was easy and then Lake Lugano to Venice was a breeze. Train is easy to access from Zurich airport. We did spend our arrival night in Zurich - not our cup of tea. Enjoy your trip.