I just returned from Munich last week and stayed at the Metropol, right next door to your hotel on Mittererstrasse--I found it to be a very convenient location as I used the Hbf every day for trains, U and S bahns, buses and trams--also the apotheke and plenty of shops for a snack or drinks for the room. I did not find the area leading from the Hbf to hotel to be a problem--and the street has no bars or restaurants on it, just 1 block long, so my street-facing room was extremely quiet. I didn't see any bars or strip joints between the Hbf and Mittererstrasse.
It's also very easy to get from the airport to the Hbf, then just 3 blocks to hotel. I used the Lufthansa Airport bus (18 euro roundtrip), but the S bahn is also a great option and a bit cheaper--the Munich airport website has details about both. If you are standing in the middle of the Hbf facing the train tracks, exit to your left, that's Bayerstrasse, then cross the street and head right a couple of blocks to Mittererstrasse, you can only go left on it.
I didn't dine anywhere near the hotel, but my favorite place ended up being the Hofbrauhaus--I liked the sauerbraten and the sausage platter the most. I sat on the terrace off the second floor, much quieter, though it overlooks the beer garden below.
If you don't already have it, I suggest getting Rick's Pocket Munich--perfect size to tuck in your purse, all the info you'll need to determine what you'd like to see, plus a map. Here's my trip report, ignore the whining about my bad back--I loved Munich despite that!
https://community.ricksteves.com/travel-forum/trip-reports/munich-it-was-the-best-of-times-it-was-the-wurst-of-times