Where would you go after 10 days in Italy?

Undoubtedly you will get many great suggestions. To answer your question, I would probably choose Amsterdam. Very accessible on a return flight to the States. Fantastic museums, architecture, history, beautiful canals, fun people. Something for everyone.

Since you are going to be in big cities for the 10 days in Italy, why not go to the countryside for the wind down at the end? Southern France is a great place to relax and just wander...in Provence you could just settle into Aix for a couple of days or go a little further west to Pezenas or Narbonne. Both would be great places to walk, eat, drink wine, and enjoy!

What are your flight plans?
Direct flights to Boston from London, Dublin, Paris, Amsterdam, Rome, Frankfurt, Madrid, Istanbul

Why not stay on in Italy? I'd consider taking the train down and seeing Sorrento and the Amalfi coast,

I'm with Lisa. Take in the Amalfi Coast before taking a fast train from Naples back to Rome.

Anytime you can fly non-stop back to Logan Airport, take it. Long flights are hard enough without having to sit around an airport 1/2 day before heading west.

I would stay in italy thereis so much to see and do. Italy is a blckbuster of incredible sigs. I am still returning after 30!yrs. if rome is your ast sto then go south to napkes, sorrento and amalfi coast. You will not regret it. It is drop dead beautiful , donot miss it can u can reach most by train and bus.
Enjoy.

I too think heading south to the Amalfi Coast is the most logical idea if you are just considering 4 or 5 days.
It's just not worth getting on a plane for a short stay somewhere before another flight home.
From a base in Sorrento you have days trips to -
--Pompeii & Herculaneum
--Naples
--Capri
--Positano & Amalfi

Thanks for the ideas. We never considered staying in Italy, figuring that would be a reason to come back (as if we need one). We were originally thinking of something more along the line of a layover stop. Break up the flight on the way back and get a taste of someplace to visit in the future.

Hmm...if you don't want to stay in Italy, and want to break up the flight, then you need something north or west. It's only a few days, so you probably want to stay in a city that has both flights from Rome (if that's where the tour ends) and flights to your home. After a city tour, I'd be tempted to go somewhere a bit more rural, but the transit concerns make staying in a city with a major airport the most logical. Amsterdam, Paris, or London would be obvious. They are on the way, have major airports with direct flights from Rome and to the US.

If this were summer, I'd say Iceland - looks beautiful and definitely breaks up the flight. But maybe not in March (I'm not sure about that but just a guess!).

Paris is always a good idea!

I would recommend adding one more day in Venice and one more night in Rome. I always feel like I want one more day when I'm on tour. I second the vote for the Amalfi coast. Its a great day base for Naples, Capri, Sorrento, Positano, Pompeii, etc. Otherwise, look at the direct flight options from your home tome and add a logical stopover. From Seattle it would be Iceland, London, Amsterdam, Paris or Frankfurt. I personally wouldn't pick Frankfurt. :)

I agree with Jenn about spending an extra day or two in Venice and Rome to see and do more than what the tour covers.

If you decide to stop for awhile in Amsterdam, Paris, London, Madrid, or another connecting city on the way home, you'll probably spend least if you book "multi-city" from Boston to Venice and from the connecting city back to Boston, then use a European budget airline to fly one-way from Rome to the connecting city. Skyscanner is a good way to find such a flight.

lf you are in Rome, consider Orvieto. Either a day trip or spend a night or two.

London!! Thats what my friend and I did after 10 days in Italy a few years ago. Much as I love Italy, the food and its people, it was very nice to stop at a place where people spoke English and there was a great variety of food. Being Asian, I was craving my rice lol! I would suggest a minimum of 3 nights wherever you stop as that will give you 2 full days of sightseeing.