It appears doubtful Americans will be allowed to travel into Italy for a vacation. Restrictions are still set.
For the heck of it, I "booked" a trip from BOS to FCO for December. My go to airline is British Airways - always had great experiences each trip to Italy. Right now, their prices were high. My last trips, I got RT fares for about $550. The dates I chose for the mock booking, fares were starting at $504+ one way. (Usually by August, the fares are half of what they start out for December.)
I then peeked at Aer Lingus on their direct site. They are promoting great fare deals. Since they are part of the alliance with BA, I plugged in my dates. RT airfare $525 - pretty much the same time slots I like except the layover/transiting was a bit shorter but nothing to stress over if plane was a bit late.
Aer Lingus had plenty of great seats available. I went through the whole booking until "payment" then cancelled.
The low RT fare was tempting to secure but with things changing daily, I figured it was not worth the risk to tie up the funds. Sure, if the flight(s) get cancelled, I probably would receive a credit or voucher for next time. For me, it it not worth the hassle right now.
It appears, you can book your reservation with no alert; although there is no guarantee you will be flying from the USA into Italy unless you can quarantine for 14 days. Things may change over the next several months. Still, if there is another wave of the virus, travel will be locked again.
It's galling to see or hear people in their defiance of mask wearing where they should. "Their rights, blah blah." What about the rights of those who do not want to get sick? Use common sense. Then there are those I see driving with a mask on....