Well, Lugano is in the Canton of Ticino in Switzerland and is only a very short bus ride along Lake Lugano from Menaggio. A simple ferry from Varenna to Menaggio then bus to Lugano. Very easy, very scenic. Sit on the left side of the bus for the best view.
Or, take the boat from Varenna (scenic and slow) all the way down the Como arm of the lake all the way to Como and get the train from there one stop to Lugano or stay on all the way to Luzern (probably via the short connecting train between Arth-Goldau to Luzern.
Lugano, and the entire Ticino Canton, speak Italian. It is quite scenic, and if you take the funicular up the mountain San Salvatore the views can be quite magic.
There are very easy train connections all over Switzerland from Lugano. A train ride form Lugano to Luzern is beautiful as it winds over and through the passes of the Alps, crossing past the same church 3 times as it gains or loses altitude.
In Luzern the town is beautiful with an ancient (actually rebuilt after a fire) painted wooden covered bridge across the lake, passenger ships all around the Vierwaldstaettersee (Lake Lucerne) with fab views up into the Alps, a ride up Rigi (a beautiful mountain with incredible views), and up Mt Titlis which has a revolving gondola on the way up and down. All these are reachable by foot or transportation from Luzern station in just a couple of minutes. Very special. Luzern is in the German speaking part of Switzerland.