Prague-Amsterdam train

The official website is here:
citynightline.ch

You can check schedules fares and book tickets 90 days in advance. They are two fares available. One refundable/changeable and a cheaper non-refundable price.

The deluxe sleepers includes toilet/shower/sink. In addition the cabin also has table/chairs, and lots of storage space for your bags. The beds are configured so that you can see scenery while you are laying in bed. I've used City Night Line's deluxe sleepers a bunch of times, and they are a great way to travel. Highly recommended!

According to the Bahn website, the advance purchase fare for a "deluxe" single sleeper on the night train from Prague to Amsterdam is 199€/P. If you purchase the ticket at the time of travel, it's 296€/P, but the train might be sold out at the time of travel.

It'd be much less expensive and quicker to just take EasyJet.com to Amsterdam.

By train, you leave Prague at 6:29 PM and arrive in Amsterdam at 10:00 AM the next morning. The entire trip costs 199€. You can have dinner on the train.

By air, to get to the Prague airport 1 hour early for the only EasyJet flight of the day at 5:05 PM, you have to leave Prague by 3:30 PM, maybe 3 PM. By the time you get to Schiphol, find the train, get into Amsterdam, and check into your hotel, it will probably be close to 8 PM and you won't have had dinner, so that pretty much shoots the evening. You have have to pay for the bus to the Prague airport (~5,50€), about 50€ (min) for the flight to Amsterdam, 4€ for the train into Amsterdam , then something for a hotel in Amsterdam. You're unlikely to get out of your hotel in the morning much before 10 AM.

You might save a little money, but you'll have less time in Prague. People seem to forget that there is a lot more involved with flying than just the time in the air.

But to Lee's reply you must also factor in the personal cost of the minimal amount of sleep you may get in this situation. We do not need a second zombie-like jet lag day, particularly one that starts early in the AM.
And perhaps this means less time in Prague, but it also means more time in Amsterdam, as in that evening.

I have been on this particular train, R/T, Amsterdam to Prague. Our family of 4 took a cabin with 6 beds- more headroom for the lower bunk, so not the deluxe sleeper you seek. It was more than tolerable during the early evening ( supposedly A/C but felt nothing, thus noisy with the window open) but some of us woke up when stopping in different cities during the night. Might be more tolerable with wine. I was quite draggy when we got to Prague and am grateful to Dům u velké boty hotel for having our rooms ready early so we could nap.
It was a travel experience I might never repeat, tho I would consider it again. Daytime trains have been far more pleasant in my experience.

Although I am one who can't sleep a wink sitting almost upright in an aluminum can packed with people, with the roar of jet engines, I have spent 10 nights on trains, always in private compartments, and had no trouble sleeping.

If you can sleep, night trains are a great way to utilize otherwise "dead" time to get to your next destination. Think about it, with a night train, you get two days of sightseeing in two venues and use the sleep time between the days to get between the venues. If you fly, you spend most of your usual sightseeing time getting between venues. You spend a day of vacation traveling and have the expense of two nights in hotels instead of one night on the train.

That said, I prefer to travel slowly within one area, seeing all there is to see there, instead of having to travel hundreds of miles to some far-away destination. Regional day trains and buses, for short travel times, work for me.

And, BTW, that night train (CNL 456) stops in Dresden-Neustadt just after 9 PM. The next stops are in Berlin, 3¼ hr later to board passengers, then 3½ hrs later in Bielefeld to discharge passengers. So, if you get to sleep early, you should have almost 7 hrs of sleep time with only 2 interuptions, 11 min apart.