We have plans for Italy in September, for about 3 1/2 weeks. Plan A is to fly in and out of Rome, with most of the time in Sicily and some time in the Naples area. We have a list of hotel options, restaurants scouted, a plan for transportation including budget air, rental car, and train. At this point, we only have reservations for the first two nights in Rome, and may not make many more.
Plan B is to just get to Rome, then lay out a plan based on what regions are open. Sardinia good? go there, North is fine, then re-visit there.
Plan C would be to modify the tickets to a completely different destination. Greece likely will be open, maybe Croatia, who knows.
We used to travel more by the "seat of the pants" so have no problem winging it, we recently retired, so no firm schedule, might be fun.