I roll my clothes. Everything is rolled individually. It works fine with wrinkle resistent clothes.
Bundling is probably better for wrinkles but I didn't like it. When you are on the road, you can't reach into your bag and pull out a single item.
Example,You spill something on your pants and want to change. With rolling you can go to the toilet, pull out a pair of pants and change. With bundling you have to pull the whole package out then repack (very ungainly). Another example, You want to add a sweater for dinner but can't just pull out the item without messing up the whole package.
IMO bundling works best when you will be unpacking and repacking only rarely on the road (cruise?).
Rolling is easy. I start by folding to a consistent width that will fit into my bag. My clothes go in vertically to add stiffness to my carry on. If you have a roll on, putting them in horizontally rolled to the width of your bag works just as well.
For shirts and sweaters, I fold the sleeves in and roll from the bottom to the top then put two rubber bands around them (one rubber band works fine, I use two in case one breaks or needs to be borrowed). Pants are rolled from the legs to the waste. I fold to half the height of my bag and do two rows (22" bag, eleven inch rows). My spare shoes go in the bottom corners facing the sides.
Loose stuff (socks and underwear) are put in a big ziplock bag. I sit on them to compress the air out, seal and put in the mesh pocket on cover of my bag. Bring extra ziplocks for dirties, wets, receipts, etc. Papers, books, shave kit etc. all go in the organizer pockets on the outside front of my ebags convertible.
I cinch the whole thing down with the compression straps to keep it all as compact as possible.