HELP! Where to Go

We want great tours, great restaurants, wine tasting etc

That sounds like Provence to me. I would stay in Avignon. Various family members, including myself, have used this company for great tours:

https://www.provence-panorama.com/category/regular-tours-from-avignon/

The bike race Paris-Nice is generally run that first week or so of March and is dubbed "the race to the sun" - usually appropriately. You see the dreary weather up by Paris eventually change to more pleasant racing as the event approaches the final stage into Nice.

Nice might be quite nice and offers lots of side trips along the coast to see the soon-to-be bustling Riviera a bit less crowded.

Provence is great, but I believe the mistral is a pretty significant risk at that time of year.

There are many interesting places in northern Italy that wouldn't require you to fly to a distant destination. With only five nights available, I'd take a hard look at how much transportation I was committing to. I don't believe you'll find any non-stop flights from Florence or Pisa to either Nice or Marseille, and a connecting flight is likely to chew up nearly an entire day when you consider the total time needed to get from hotel to hotel.

Wikipedia: Flights from Florence
Wikipedia: Flights from Pisa

I couldn't find any non-stops from Bologna on Skyscanner, either.

jgoldberg1510,
What about southern Italy (Sorrento, Naples, Amalfi coast, Pompeii), or Sicily? Five days won't cover all there is to see and do in Sicily, but you could still see a lot.

I went to Google Flights and found the most direct flights from Pisa, which is an easy train trip from Florence: Paris, London, Brussels, Amsterdam, Prague, Berlin, Budapest, Bucharest…. and a few others. Of course, I used random March dates, so the choices might change by date.

I would definitely choose a city in March, in case of inclement weather. With 5 nights, why not try something completely different and head to Budapest? It definitely has great tours, great restaurants, and great wine.

You are always welcome here...
Second choice, Istanbul.

For your March trip, considering you've already been to some key cities, here are a few great options that offer excellent tours, dining, and wine experiences:
Tuscany Wine Regions (Chianti, Montepulciano): If you're a wine enthusiast, staying within Italy but exploring the countryside could be fantastic. You can visit vineyards, enjoy local cuisine, and take guided wine tours.

TTM, Ryan flies from Pisa to your Budapest nonstop starting at 41 Euro. 1:40 flight, so hotel to hotel maybe 5 hours.

World class wine and tastings and vineyard trips. More good food than what seems to make sense for one city. Crazy freaking beautiful and nice in March. Did I mention the prices?

Anyway, my favorite videos of the city can be found by clicking on my name.

thank you so much...this is in Budapest? Sounds perfect

jgoldberg1510, Budapest is definitely one of my favorite cities!

For the wine tastings, how about you do them at a few wineries? I know a good guide for that.