If the cheapest flight lands in a city that's far from what you want to see, you may chew up quite a bit of money (and valuable vacation time) in-transit. If you settle for the lowest possible fare and it's in a location that doesn't interest you, do factor in the extra costs of getting to where you actually want to go.
Tom beat me to it, so I'm putting what he wrote in bold because it's so important. One poster here got a cheap flight to Stockholm (probably on Norwegian), but had no interest in Stockholm, or Sweden, or even Scandinavia; she wanted to go to Italy on that trip. She may have "saved" on her flight to Europe, but spent a lot of extra time, money, and aggravation getting to and from Stockholm to Italy - a very bad deal, in my view.
So, don't just look for a cheap flight to "Europe," unless you really don't have a more specific destination in mind. Do keep in mind that for a particular trip, you may do better using airports that don't get nonstop flights from the US. For instance, when going to the France, you don't have to fly into or out of Paris if that's not part of your itinerary. There are major airports in Nice, Marseilles, Toulouse, Bordeaux, and Lyon, all with connections from various European cities (you don't need to change through Paris); that's not to mention smaller airports in the country that mostly get service from Paris and could also work (like Montpellier).
If you want to know who flies where nonstop from an airport, look at that airport's Wikipedia page. Here's the one for ATL: https://en.wikipedia.org/wiki/Hartsfield%E2%80%93Jackson_Atlanta_International_Airport#Airlines_and_destinations