SJC: I have traveled multiple times to Europe with my CPAP. The concern is generally at the departure airport and not the arrival airport. You will be screened upon departure from the US and the DHS security folks are quite familiar with CPAP machines. When I have traveled by air within Europe, I have not had any screening problems with the security folks at the various airports. I have a letter from my doctor and prescription for the CPAP, but I have never had to show them. I would recommend that you review in advance the procedures for on-board baggage for each air carrier and ensure that you understand them, meet them, and will be in compliance with them. Depending upon the air carrier, they may want to know make, model, serial number of the CPAP and they will enter it into their system and will consider the CPAP as a medical device and as an additional in-cabin piece of baggage (without charge). Take an extension cord as your bed may not be situated near an electrical outlet; and, ensure you have the correct plug adapter. Also, check your CPAP power source to ensure it supports a voltage range between 100 and 240V--most newer models do, so this shouldn't be an issue; however, if it is, you will need a voltage adapter as well. Enjoy your trip.