This really depends on your taste. For me:
Prague: A Disneyland utopia with overly restored, but stunning, medieval architecture and wall to wall tourists all gawking at the same clock.
Belgrade: Great young party town with maybe two days of historical context and sights to see. But i did enjoy it.
Sarajevo: Not impressed with what i have read. But on my radar for some day.
Ljubljana: Too hard to get to (too long actually) from Budapest
Zagreb: See Ljubljana above.
Flyover to Paris or Lyon (never been to France): I love Paris! But i would stick to Central / Eastern Europe
Flyover to Brussels (never been): Just didnt light my fire.
Okay, now that i butchered your list. Here are my favorites, but first, its going to be about the day of the week because there are all short discount fare flights (mostly under $90 and 1.5 hours):
A lot of names here. What i do for starters is just put the name in Google Images and see if i like what pops up. If yes, then i begin the research.
Titograd (Podgorica). Not so much for the city, but because its a short trip to Budva and the coast. Its also a short drive to the mountains if you are into nature, fishing, old monastery built into the side of cliff, etc. I love Montenegro. Two trips so far and a third soon. I know a young lady that is an excellent guide. Wizzair is under $100 on Tuesday and Thursday and Saturday
Kyiv: Oh my g-d! Into the throat of WAR! Naaa, Ukraine is roughly the size of Texas. The Russian incursion is in Corpus Christi and Kyiv is in Abilene. To be interested in this you really have to interested in modern politics and social culture. Well, not entirely as there is good architecture, some catacombs, etc. It would be like no trip you ever took before. Again, this is a place i adore. We head back in a few weeks. And I know a guide here as well. With four days you could spend two in Kyiv and two in Odesa or Lviv. Flights to/from Kyiv run daily.
Sofia: Another place i keep returning to. Okay, i am one of the few that really like Sofia, but no one can argue that its not worth a day or two. The real charm is outside of Sofia though. You will need a guide (I know a great woman). The trip would include (other than Sofia), the stunning Rila Monastery which i suspect is like nothing you have ever seen before and if you love history the Bachkovo Monastery which protected the Jews during the Holocaust. Then on to what i think is one of the best kept secrets in Eastern Europe: Plovdiv. From ancient Roman theaters and floor mosaics to excellent examples of ottoman architecture and every style since. Good food, good people. Just a dang nice place to spend a couple of days.
Wizzair is under $100 on Tuesday and Thursday and Saturday