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Best Transportation between Prague, Austria, Switzerland and Italy

Looking for the best way to travel within the below destinations in December.

Preferably train- willing to travel at night.

If train, which line?
Car? Concerned w weather in the higher altitudes
Not interested in buses.

Prague, cz
Salzburg, Austria
Innsbruck Austria
Trento, Italy (1 day only)
Zermatt, Switzerland
Interlaken, Switzerland
Luzern, Switzerland
Prague, cz

Thank you ! We did an amazing trip last year, thru many parts of Italy & Sicily via train, car and ferry.

Posted by
7055 posts

There is a night train between Zürich and Prague, operated by ČD. Book your tickets at www.cd.cz

Otherwise I think day trains are the best as the distances are a bit short for night trains.

Posted by
8889 posts

"If train, which line?" - do you mean which route (answer: the quickest), or are you asking which train company (answer: the national company, one for each country)?

Some of your trips are easier than others. Trento to Zermatt in particular will take all day (~8 hours).

I suggest you start with the "Man in Seat 61" website: https://www.seat61.com/Europe-train-travel.htm
This website has sections for each country, and in many cases pages for specific routes, describing the services and where to buy tickets.
For example, Prague to Salzburg: https://www.seat61.com/trains-and-routes/salzburg-to-prague-by-train.htm
Salzburg to Innsbruck: https://www.seat61.com/international-trains/trains-from-Salzburg.htm#Salzburg-Austria
etc.