I am in the last steps of planning the itinerary for a 3-weekish long trip of Europe for summer 2016.
In a nutshell: I'm Deaf. I consulted over 20 travel/tour agencies (including RS) asking if ASL interpreters would be provided - and got a NO from all of them. (RS did send a very nice detailed email about travelers with disabilities). Most of the groups that cater to travelers with disabilities aren't Deaf friendly (as our barrier is a sociolinguistic one more so than a physical one). I did consult several Deaf travel agencies but they mostly do cruises or one-country trips. I, myself am losing vision (Usher Syndrome), so a longer multi-country trip is a priority to get the best of in one go before my vision deteriorates (if I have usable vision in the future, then more trips are in the works!) This particular tour agency has a customization option (which is great, considering some of my must-dos are not usually highlighted on other itineraries).
Note: the city tours are walking tours led by local Deaf guides. I believe there is one Deaf guide at the Louvre as well as the Coliseum. Not sure about the others yet.
The Munich-castles-Rothenburg-Munich portion mostly likely will have a car/van while the others will use trains/local transportation.
Edit: New itinerary posted 10th of Sept in a post below
Day 0: Departure (overnight flight to London from the US)
Day 1: Arrival; British Museum in the evening (stop at Hamley's toys to pick up the one Playmobil set that is exclusive to the store) Edit: Exchanged BM with Tower of London/Bridge.
Day 2: Harry Potter Studio Tour (Evening Optional: West End)
Day 3: Hyde Park/Kensington Gardens (Peter Pan statue); Buckingham Palace (Changing of Guard), London Eye, Westiminster Abbey, Big Ben (nighttime photo). Optional: Harrod's
Day 4: St Paul Cathedral, Globe Theater, Tower of London/Tower Bridge Edit: Exchanged TL/B with British Museum
Day 5: Eurostar to Paris (stop at King's Cross Station for photo op at Platform 9 3/4 before St Pancras); Afternoon: Eiffel Tower, Trocadero, Les Invalides
Day 6: Versailles, Seine River Cruise, Sacre Coeur/Montmartre
Day 7: Notre Dame, Arc de Triomphe/Champs Elysees, Louvre (open til 9ish on W and F)
Day 8: Departure to Amsterdam; City tour, canal boat ride
Day 9: Anne Frank House, Rijksmuseum
Overnight train to Munich
Day 10: Arrive Munich; Marienplatz (Glockenspiel), Hofbrauhaus
Day 11: Neuschwanstein Castle, Hohenschwangau Castle, drive to Rothenburg ob der Tauber
Day 12: Rothenburg: Striffler bakery, Crime & Punishment Museum? Kathe Wolfhart Christmas stuff (for a friend), Night watchman tour
Day 13: Drive to Munich; train to Salzburg
Day 14: Salzburg: city tour, old market, Sound of Music sites, Mirabell Gardens, Edit: combined walking tour with several SOM sites in the Old Town area for overlap reasons
Day 15: Salzbergwerk salt mines, Heilbronn Palace/Gardens
Day 16: Train to Venice; vaporetto ride through Grand Canal
Day 17: Doges Palace/Bridge of Sighs, Rialto Bridge, Galleria d' Accademia, Scuola Grande di San Rocco, St Marks bell tower, and St Marks basilica
Day 18: Depart to Florence; Giotto's bell tower, Duomo, Bapistery, Academia
Day 19: Palazzo Vecchio, Ponte Vecchio, Uffizi, Basilica di Santa Croce
Day 20: Depart to Rome, city tour, Spanish steps, Trevi fountain, Piazza Navona Edit: moved Pantheon here for local proximity purposes
Day 21: Coliseum, Forum, Pantheon Edit: moved Pantheon to Day 20
Day 22: Vatican City, St Peter's Basilica, Sistine Chapel, Vatican Museums
Day 23: Depart for the US