jenn,
"We're not worried about driving. Husband prefers it...he'd drive the whole trip if he could."
I must have missed that you were planning on driving. There are also some potentially expensive "caveats' for driving in Italy. Where are you planning on renting the car?
Note that each driver registered on the rental form will require the compulsory International Driver's Permit, which is used in conjunction with your home D.L. These are easily obtained at any AAA office for a small fee and are valid for one year.
You'll also have to familiarize yourself with the dreaded ZTL (limited traffic) areas which exist in many towns in Italy, as hefty fines will result from each pass through one. Do NOT drive in Florence as the city is just about saturated with automated ZTL cameras, and you won't find out that you've been "nicked" until several months after you've returned home.
In addition to ZTL, you'll also need to be vigilant to avoid speed cameras including the devious Traffic Tutor which measures not only instantaneous speed but also average between two points. Violate either or both and expensive tickets will follow. Be sure to budget for tolls on the motorways and parking. A GPS along with a good map would be prudent.
You may find these websites helpful.....
http://www.slowtrav.com/italy/driving/traffic_cameras_speeding.htm
http://www.autoeurope.com/go/italy-ztl-zones/