Suggestions for 14 days: LAX to AMS, onto Prague, then Villeseque, France and then Porto, Portugal Feasible. Sensible? Feature of the trip is visiting my dear friend in Villeseque. Starting in AMS bec Van Gogh museum. Prague & Porto because have heard such praises. Alternatives instead of Prague, head to Florence or head to Madrid
Although lovely places individually, I feel you will be spending as much time in airports to complete this itinerary, as you will seeing the places. I would be inclined to simplify my trip down to 3 places, and also make sure that my arrangements for Villesque were my focus. Was your plan to fly into Toulouse then rent a car, or train?
What about flying into Amsterdam, train down into France, then train on to Barcelona to fly home from? It's much closer than Madrid or Porto. At the very least I'd drop Prague
For the time you have Prague looks too far off an efficient path, unless you you do Amsterdam, Villesque and Prague and return home from there.