Evan
We did a Central Europe trip in 2018 that was 3 days in Prague, 4 in Vienna and 11 in Croatia. So I’ll pick up your invite to talk about Croatia a bit.
Zagreb was a more minor, regional capital of the Austrian Hungarian empire and lacks the spectacular sights of Vienna or Prague. But its Museum of Naive Art was charming and its old town was accessible, walkable and a treat for a few hours. We were only there 24 hours, which may not have done it justice but seemed like enough. In 2018, the scars and damage of the war between Coats and Serbs related to the dissolution of the former Yugoslavia was very much still a presence, as was the Stalinist style, Tito era buildings just beyond the limits of the old city.
Plitvice Lakes NP is spectacular. Its quietness and small waterfalls and lakes everywhere was as enchanting to me as the grandeur of Yosemite’s towering cliffs and waterfalls. We headed to the Dalmatian coast and stopped at Zadar, Krka NP and Trogir on our way to Split. The two small cities were charming, not spectacular, and reflected their past as Venetian outposts 500+ years earlier. Sadat in particular had a wonderful vibe.
Split has an interesting history and the legacy of Diocletian’s Palace and Roman and Venetian influences was lovely, as is its setting, though I wouldn’t consider it a great city. We did have some lovely food in Split and elsewhere in Croatia. Italian influenced; seafood, pasta and meats. Somehow it all started seeming to be the same after a week, however.
We did our first bike trip in Croatia. It was a guided trip and we loved it. The company that ran it was based in Split and they were tremendous. https://www.meridienten.com/ I highly recommend them. They have both guided and self-guided tours. It was 6 days of cycling: Split, islands of Brac, Hvar and Korcula, and finally cycling and van transfer down the Peljesac Peninsula to Dubrovnik. The islands are charming and, as I mentioned before, cycling is a wonderful way to get around and see more - beyond the tourist track. One thing about the islands, the beaches are pebbly rather than sandy. Dubrovnik’s old walled city is spectacular, but tourism and tour boat impacts are significant.
Split would not be a bad base. Krka, Zadar, Trogir, and many islands are accessible as day trips from there. i'd say Plitvice and Zagreb are too far as day trips. Not sure about Dubrovnik, esp since you can now drive between Split and Dubrovnik without having to cross a border for Bosnia.
Our trip did not include Istria, which is close to Venice, heavily influenced by Italian culture and which was part of Italy prior to WW2. IF I have managed to interest you in cycling, Meridien Ten offers trips in Ischia, as well.
As to where you should go, that’s for you and your wife and companions to decide. You will eat better in the Dordogne.