(Edited to correct typo in my post):
Frank, good question. Interesting answers from other posters.
It will be a multi-stage gradual process for me:
Step One: Feel comfortable going into Costco at a time other than early senior hour on Tu/Th.
(Did so ONCE outside those hours, and I was shocked at the number of UNmasked customers and the crowds.)
Step Two: Feel comfortable doing my normal in-person grocery shopping (have been doing curb-side pick-up for 99% of it for the last two years).
Step Three: Feel comfortable gathering with friends (did it once in June last year/patio dinner at our home)in such a way that we would be 2-3 three feet away from each other without masks, attending a wedding or even a baby shower with the acceptance that all might not be vaccinated or some could be asymptomatic vaccinated carriers.
Step Four: Feel comfortable dining INSIDE a restaurant. That will be a biggie when that level of comfort arrives.
Step Five: Feel comfortable enough to take my mask off on a plane to eat/drink QUICKLY.
Step Six: A 70 or greater percent of vaccination (and a relatively low case count) among the population to wherever I might consider traveling.
What will help to move me along the various steps? A much higher percentage of individuals being vaccinated and a reduction in the number of new variants that pop up, (realizing variants will likely always continue to pop up). Sadly in my state of Tennessee, the vaccination percentage is only about 50%. State legislature and Governor have outlawed required blanket mask mandates (except in medical facilities that accept Fed insurances, Fed buildings, etc. and individual venues can choose to enforce mandates) and very sadly, if you were to visit Tennessee, for the most part, and for the majority of the public at large, mask wearing would be the exception...and a good number of people think wearing a mask UNDER one's nose counts. So, it could be a really long time locally. Currently about (edited to correct typo) 1 of every 30-35 residents in TN (Nashville area...maybe worse in some rural areas) are assumed to have active covid, and respected medical advisors have recently reminded (on local news) that anytime one is out and about (especially inside) among the public, you can pretty much expect that you WILL be exposed to someone with covid. Yep, so being vaccinated, wearing an N-95, etc.and keeping distance is prudent.
OK, one could argue other countries are safer.....yep, maybe. But, for me (and that is what your question asks), it will be comfort with the 6 steps listed above.
We made international travel a huge priority for many years, visited all 7 continents (Europe multiple times), along with Greenland, Iceland, and New Zealand (two of which are technically separate continental shelves, if I recall correctly). We always reminded ourselves to travel while we could, because we never knew what the future would bring (well, duh, little did we know it would be such a yucky whopper of a darn global pandemic...I mean really!!!!).
Places we would still like to visit include Egypt, Jordan, India, more parts of South America, more parts of Africa, etc. Every so often, I check vaccination percentages for some of those places, and I am not comfortable....far from it. So, until then, we are thankful we traveled as much as we did when we did. And, how I hope a level of comfort is achieved, as there is still so much to see.
I need to seriously acknowledge that MANY....well, MOST, people that are traveling (and practicing precautions) are doing so successfully and without major setbacks (other some changing rules in various places, some airline cancellations, weather issues, etc.). So, to those of you who HAVE achieved your comfort level, be safe, be cautious, and Godspeed to you!!! We never know what the future will bring; that sure has been proven!!