"Best" is subjective. All other things being equal, I'd pick Turkish Airlines over any alternative. Great airline.
That said, it's probably going to depend mostly on what your destination would be, and how much you care about a nonstop flight to your destination (there are some of those - to Frankfurt, Munich, Amsterdam, Paris, Dublin, Brusels, Stockholm, Copenhagen, Athens, Milan, Geneva and more...plus multiple UK airports which you want to avoid...). If you don't mind connecting in Istanbul, there are plenty of choices. If Italy is your target, there's a nonstop flight to Milan on SunExpress (a Turkish-German low cost airline). If you don't mind a stop in Istanbul, you could get to almost anyplace in Europe with that one stop (including several Italian cities).