Have you spent time in Istanbul before? Unless you are especially interested In spending most of your time on the Asian side of the city, I would not choose to stay in Kadikoy. It is a long and time-consuming way from most of the places you are likely to want to visit in Istanbul. Sultanahmet is certainly a very popular place for visitors to stay, as there are many small and some larger hotels, and it is very convenient to many of the most historic and beautiful sites in Istanbul. Also nice to be able to stroll there in the evening and nighttime, when things are quiet and many major sites are illuminated. No reason to “avoid” Sultanahmet, in my opinion. I myself have stayed 3 times at the wonderful Regie Ottoman Hotel in Sirkeci, about mid-way between Sultanahmet and the Galata Bridge, easily walkable to either one. Lovely old building, large and comfortable rooms and bathrooms, friendly and helpful staff, great value for the quality, I thought. They also served a varied, abundant and delicious buffet breakfast, at least they did pre-pandemic.