Shalom Daniel. I've flown that SFO route in the past and more recently TLV-ORD-TLV at least 3 times in recent years, the most recent this summer. The IFE is good, the food is good, the service is good. There was no alcohol on the flights this year, I assume because of Covid. On both long-haul flights everyone got a little travel bag with toothbrush, paste, slippers and eye mask. Also, they gave out packets of disposable masks and sanitizer wipes on boarding each flight. Between meals the galley at the rear of the plane is open, with snacks (cellophane wrapped cakes, cookies) and drinks - coffee, tea, fruit juices, coke, etc. BTW Turkish sour cherry juice is yummy. Most seats have a USB port so you can charge devices in-flight, though not all of them work. I think they also have an electrical outlet, but again, not all work. I can't remember whether the outlet is US or European (Turkey uses European), so maybe bring an adapter on the flight (you can also use it in the IST and TLV airports). The IST-TLV flights are on much smaller planes without all the bells and whistles. OTOH it's only 2 hours. They did serve a light meal on the flights. Also while Turkish is generous with 2 free bags, they are strict on weight limits - and usually weigh carry ons (7 kg limit).
How long are your layovers? I usually book the shortest possible. When I check in I make sure my bags are tagged to my destination and also tagged "short connection." (in the past, I've had checked bags that didn't make it to the plane more than once. To be fair that's happened to me on other airlines as well).
Neither the US nor Israel trusts Turkish security completely. You will go through a second security check in IST at the gate to your next flight. This includes passport checks, seeing your negative PCR test, a hand search of hand luggage and they wand bodies. I found it easier to get through the new airport than the old one and with less than 2 hours layover, I had more than enough time. If you have longer, there are plenty of restaurants, shops and kiosks. I think all the bathrooms are now "western." The old airport had a mix of seats and squatters.
Have your family filled you in on all the hoops you need to go through for Israel? PCR tests, online forms, etc. Only passengers are allowed inside the terminal. If people are meeting your flight, they have to wait outside. And you need a credit card to pay to get a luggage cart. Still the same crappy carts, though.