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Travel from Florence to Avignon

We will be staying in Arrez in Tuscany & traveling to Avignon in Provence on a Saturday. Any suggestions for this itinerary? Will consider flying or rail travel. We could also leave from Pisa or Sienna.

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See flight options from Pisa or Florence airports to Marseille/Provence airport at www.skyscanner.com. Trains from the Vitrolles Aeroport Marseille station (take a taxi or shuttle bus) to Avignon take one hour and don't need reservations.

Train connections from Arezzo to Avignon Centre take 11-13 hours, with one of the better connections departing at 6:00 a.m. How to Look Up Train Schedules and Routes Online gives you the DB train schedule link and tips for using it, but ticket purchase would be through Italian and French web sites (or Rail Europe or Captain Train) for 5 train legs, all reserved.