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Transportation from Germany to Italy

We would like to know how we travel either by train(preferably train) or bus from Garmisch-Partenkirchen to Siena, Italy on Sept 29/12. Is their a

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Wendy, It would help to know the second part of your question ("Is there a".....). That's going to be a LONG trip by train, but it's certainly possible. The easiest route I found was a departure from Garmen-Partenkirchen at 08:04, with arrival in Siena at 19:38 (time 11H:34M, 3 changes, reservations compulsory on 2 legs). With such a long travel day, you might consider stopping for at least one night at an intermediate point, perhaps Verona. That would break up the long trip into more easily manageable segments. Check www.bahn.de to research rail trips throughout Europe. Happy travels!