We'll be making our first trip to Europe mid-October, going to Tuscany & Umbria. I've been researching flights and it seems that flying Delta out of Cleveland, as opposed to Detroit or Columbus, to Rome is our best bet. We'd prefer to fly Comfort+ (Delta's premium economy). The plane is an Airbus 330 and the seating is a 2-4-2 configuration. I've reviewed SeatGuru for guidance but I have still some questions regarding seat selection.
Since it will be a night flight we're wondering whether we'd be better off going with outside seats so that one of us has a wall to lean on or going with two of the four and hoping that the others remain empty, giving us more room to spread. And as a sidebar, would it be bad form to choose the middle two seats to enhance our chances of the other seats remaining empty? I feel it would be but thought I'd pose the question. And finally, does anyone have a feel for how quickly this section tends to fill? The seats are currently $1477 each. I don't want to miss out by waiting too long.
Thank you for any guidance you can provide.