London to Prague One Way

I don't know what you mean by "the best way." I can tell you the cheapest way: By Ryan Air from London Stanstead to Brno. Then by Student Agency Yellow Bus to Prague.

That's an option I hadn't considered. (I have to quit using "best"--means best for me, which is confusing to others.) Do you know how long the yellow student bus ride is? Does it only carry students? Thanks.

Joan . Ha! I agree. It is best to not use "best"! Thanks for noticing. ;0)

The bus takes little over 2 hours from Brno to Prague. You can also go by train which is about 2 and half hours. Student Agency is a company which owns a bus but it takes anybody who is willing to pay not just students.