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Getting from Assisi to Urbino in Italy

I will be traveling to Italy just after Easter 2008. I am trying to figure out an Itinerary that makes sense. I have had a hard time finding a way, other than renting a car, which I am trying to avoid, of getting from Assisi to Urbino. It seems like more too much of a hassle, although, on a map, it looks like there are roads that connect the 2 cities that arent that bad, distance-wise. I'd hate to be THAT close to Urbino and not visit it. Are there any buses or even train connections that make sense? Or is it too much trouble to go through just to spend 1 day in one of the many amazing cities in the reqion? Are there any other cities west and/or south of Urbino that have logical connections with Urbino? Thanks