2 nights in Rome how to make the most of them

If I had 2 days in Rome, I would put the Vatican, Castle San Angelo that is just.outside Vatican City, & a walking tour of the Jewish Ghetto on my list of "to see" places. I have read positive reviews about Jewish Roma, a company that provides walking tours of the ghetto.

As others may say, it all depends on your interests.

I find that walking tours with live guides is a very good way to go. Spend some time with Steves' Rome guidebook. Over the years we have spent more than three weeks in Rome and have not seen everything. So you need to choice what is important to you. And we don't know that. Personally I would stay in the Termini area for quick convenience to transit which is important for a quick hit.

We hired Francesca Caruso (from Rick Steves guidebook). She is a local guide for RS and helps writes his guidebooks. There is none better than Francesca. She is featured in his travel videos too. You can tell by our compliments of her that our day tours of Rome were incredible. We booked her for the Coliseum, Pantheon, Roman Forum and The Vatican. We have only used Rick Steves recommended guides, but you won't be disapponinted if you hire any of them.
I remember seeing so many people walking around with guidebooks trying to figure out what everything was. If you can afford a guide please do it as there is so much history that needs to be explained by a guide.