Where to base in Provence?

I'd like suggestions on where to base ourselves for a week in Provence next September. We'll have a car, so finding a location with great public transport options isn't that critical. To narrow things down, we much prefer smallish towns over cities, but would like something thats big enough to have a nice ion of restaurants, shops and is also hopefully a scenic destination in itself. To use an Italy example, we'd love to find something in the same realm as Montepulciano. In terms of area, we'd like something thats convenient to the hill towns of the Luberon, the Cotes du Rhone wine villages, the area west of the Rhone. Ideal would be someplace that's not too far of a drive to a suburban train station that will allow us easy access to cities such as Avignon, Nimes, Arles, etc. My wife and I are into food and photography but aren't big museum or art people; if its important, we (unfortunately) don't speak French but do speak both German and English.