Driving to and from the airport shouldn't be too hard. You'll probably have to pay little more to pick up there, but it's much better than picking up in Paris itself (You aren't planning on driving in Paris, are you?)
I've always used Autoeurope.com. They've been very reliable and generally offer the best rates. You can go online and test itineraries for their rates but I would call them on the toll-free number because the humans seem to be able to offer better deals than the computers.
There has been a lot of discussion here about whether or not to buy the CDW insurance. Call your own agent and your credit card company to be sure you know what you already have covered.
Driving in France (apart from Paris) is easy.