Never been there.
North & West of Iserlohn is the Megalopolis Essen-Dortmund.
South and East are a series of Nature Parks & Mountains. There are several towns & villages in this area that ADAC identifies as scenic. There are also several routes that are identified as scenic. I would buy an ADAC StaßenAtlas and use it to explore the area. You can wait until you get there to purchase it or order it from Germany. Amazon.de has it.
If you want to research some towns in the area look them up on Yahoo Deutschland.
http://de.yahoo.com/
Most Germany towns have a website that will detail their tourist sights.
Regards, Gary