Casey, if you are looking for more upscale hotel rooms, there is the Victoria Jungfrau Grand Hotel & Spa in Interlaken (5-star) at up to $520/night. Interlaken is a 25-minute train ride from Lauterbrunnen. From some rooms, you have a glorious wide view of the alps. This view is not to be confused with staying in Lauterbrunnen or in the upper alpine villages where the views are closer and even more spectacular.
Next, Wengen has two 4-star hotels (Caprice Hotel and the Beausite Park Hotel. Additionally, Wengen has at least 5 3-star hotels.
Lauterbrunnen has one 3-star hotel. This is the Hotel Silberhorn which is about 500' from the train station. About $185/night. Probably the best restaurant in the valley. We've stayed there and really liked it.
The Hotel Staubbach is rated #1 in Lauterbrunnen at $85/night but I don't think your wife will like the words "charming" and "rustic" that you see in the reviews. To me, that means "old and/or needs repair". But at $85/night, it's a great value.
Not to be outdone, Muerren has one 4-star hotel at $180/night (Hotel Eiger) and one 3-star hotel at $110/night (Hotel Blumenthal). Muerren may be small but it's everything you would want to see in a Swiss Alpine village. Just stunning.