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Antwerp: Which part of town would I want to be based at?

I'm planning a quick weekend trip to Antwerp and was wondering which part of town you'd recommend to search for a hotel in. Since it's just a 4 hours drive from Frankfurt we'd take the car so proximity to the train station is irrelevant to us. Any input is highly appreciated. Thanks in advance...

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Most of the things of interest to a visitor sit in the area known as "Het Zuid", like the Grote Markt, cathedral, het Steen and the Rubenshuis.