If you want to visit the Anne Frankhuis, book your ticket in advance. It will save you the queuing up on the museum. Fortunately, the museum is located on a very nice part of the city, a pleasant place to walk by. I would do the following: Sep. 10th - after you arrive and check-in, visit the Anne Frankhuis. Book your ticket (in advance, online) on the last time slot of the day. If you arrive earlier, good for you: take a walk around. After your visit, if you are not too tired you can go for a stroll on the area between Rembrandtplent and Leidseplien - much more interesting than walking around De Wallen or other areas nearby by night. Sep. 11th - I'd make a long morning walk starting on the Voldenpark, veering left to the Jordan, then heading to the sights on the canal belt core. You can fit a canal cruise on that, depending how early you get out. I'd stay overnight on some hotel near Leidseplein. If you can splurge, there is a Hyatt close by. I would NOT stay close to the central station. It will stick you with the part of the city that looks more like a circus than anything else. You can arrange with the hotel you will be staying in (especially if it is a more expensive one) to have your luggage stored while you go enjoy the city on the morning and have checked-out. You then go back to the hotel, pick up your bags and head to the airport.