Cory,
Provided you are just passing through Glasgow on the M8 you should not have a terrible time. It is no different than driving through San Diego on I5 (other than being on the opposite side of the road). It gets a little more complicated if you start getting off the Motorway.
If you are able to get yourself started in Edinburgh between left side of the road and manual transmission, you should have no problems by the time you reach Glasgow. I would almost think that is the greater challenge.
If you have any worries take your time and choose a time to travel that works well. Drawing a comparison to San Diego again - Navigating the I5-I805 merge is much easier Saturday at 11 am then Friday at 5 PM.
If I remember by the time you reach the bridge you need to cross to get to the lochs, you have passed the airport and are really out of Glasgow already.