Venice/Dubrovnik/Prague

Our family of 4 will be traveling x 3 weeks the above itinerary. Would also plan to include Plitvice Lakes, Cesky Krumlov,perhaps ,Split and Kurcula. We will arrive in Venice and depart Prague and are looking for the most direct routes so that we do a minimum of backtracking and limit time on the road. We will plan to rent a car for some of the journey and use train/boat for some as well. We would appreciate the most effecient itinerary.
thanks!

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