Pam, your plan is too ambitious if you have only 2 days... do NOT attempt to do the Samaria Gorge; it's a full 10-12 hour expedition door to door (BTW there are over 20 Gorges in Greece, do not call it The Gorge; that's like saying I'm going to New York to see The Skyscraper). You can easily fill a full day exploring Chania... and on day 2, why not go to Vamos? (google it); great village to explore & they offer shorter walks from there.You can rent a car MOrning of day 2, and drop it at airport on departure.
RE Arrival: you get there 7:30... It will be light until about 9 pm, so you could get half-way there, maybe Rethymnon before it gets dark & the highway is modern, but it can be stressful if new to you. Why not relax? there is a bus at 20:00 (8 pm) and 21:00 (9 pm). The bus station is right next to your pier. You can make the 8pm one if you make sure to Be first in line to disembark and run Right OVer to the bus terminal. There are 3 of you, 2 can retrieve the luggage. 1 can run ahead to ticket window. Then u can enjoy sunset & view out of the bus window (seats are numbered; get seats on RH side).
Safety for women is not an issue in Crete, or really, in Greece; lowest crime rate in Europe.