I am planning a trip to Germany, Switzerland and Prague in Summer 2011 with our two girls. Should we drive to Prague or take our rental car. If we take the train what is the best German town to take the train from
Go by train. Dresden. It's the closest and there are direct trains to Prague. If you are not going to Dresden then I would suggest Berlin. Also direct trains.
If you do decide to drive, you need to inform your rental car company. There are only certain cars they will allow into Eastern European countries. Have a great trip!
The train from Berlin to Prague (also stops in Dresden) is a nice, easy ride.
I second the idea of train from Dresden to Prague-- we did it last spring and it's really easy and not expensive.