Prague

My vote goes to the Golden Well. It's awesome. Of course, it's also the only expensive hotel in Prague that I've actually stayed at. www.goldenwell.cz

Don't know about best because that world doesn't have much meaning out of context. During this past New Years we stay at the Hilton right on the edge of old town. It was very nice and great service, and excellent location. Do not know why you would want any more.

Golden Well is definitely the top choice if money is no object. Not sure why you would want to go with an expensive hotel when there are many good options in all price ranges in Prague. Just because a hotel is expensive does not mean it is better than some of the moderately priced places.