Krakow to Prague

There are several options but all (with the exception of one) require train change. The only direct train is overnight. Leaves Krakow at 21:54, arrives in Prague 07:50.

Awesome! Thank you. Are the transfers difficult to make?

Transfers are not difficult if you don't have heavy luggage. When transferring you have to know what train (destination) you are looking for. In some bigger station they also announce trains in English.