Need an old town hotel with good access to the Trolley, think the Sultanahmet area is my best bet. For medical reasons I like to use mass transit as much as I can. Prefer three star, clean, neat, etc. for two week stay. Thanks for your suggestions.
St. Sophia Best Western.
The Empress Theodora Hotel - super close to the tram and all the attractions. If you need a quiet room, you may be better off asking for one that does not face the street. I enjoyed staying there, although the rooms are a bit on the small side. Booking.com should get you a decent rate.
sokullu pasa hotel is quite nice.