Hi Jaime, Almost every winter I go to Czech Rep with my Czech national husband & we do alot of driving there and all over Europe. November can be a crap shoot for weather conditions in central and eastern europe, but do count on it being colder the farther east or north you go. I've been there when it was too cold to snow & had to wear a scarf over my nose and mouth not to burn my lungs when I breath. I've also seen a few great, clear days in the low 50s. Black ice on the roads are commonplace. Snow too, but not in recent years. The days get shorter each day by about 2 minutes, so plan on only 8 hrs of daytime. If you are driving from Salzburg to Prague you probably will drive the route going near Cesky Krumlov. Unfortunately the castle is not open during that time or I would recommend you to break up the driving by staying there. Are you going to hit Vienna at all? Plan your route by visiting Vienna after Salzburg and then driving up to Prague from Vienna.