Yes. If you do maps.google.com and put in Zurich Airport, you'll see the train symbol right near the terminal (near a Migros market). Plus, it says on Google: "Airport with domestic & international flights, 3 terminals, a railway station & bus links."
Find the ticket office for the trains near there. They'll speak English. Say you want to get to Grindelwald, BUT ask to be routed via Luzern as it is a more scenic route. You can even stop awhile in Luzern (Lucerne) to look around, as you have to change trains anyway. If you ask, the agent will print out a slip with the times and tracks listed on it. You might even say that you might stop for an hour or so in Luzern, and the agent can give you times for the following trains (generally every hour).
There are storage lockers on the lower floor if you don't want to lug your luggage thru Luzern. Still, even if you have a few minutes between trains, it's worth getting up to street level to take a look as you are right near the lake. You'll see a view pretty close to this:
You can plan all sorts of train excursions from Grindelwald, though I'd wait until you get there to get tickets (rarely any discount for advance purchase). Besides, you might just decide you want to explore the Jungfrau area around Grindelwald. There are plenty of sights and trails. If you click on my name you'll find a link to a website where I describe our dozen favorite trails in the area, with maps and pics.