UPDATE: Thank you so far for ALL the guidance. The problem with leaving at 6:28AM is that we have to take a cable car from Murren and bus I believe to Lauterbrunnen and that takes time and not sure if they would get there by 6:28am. If we decided to break the trip up from Murren to Siena since it seems like too long a day based on replies - where would a good place to overnight be? We would like to make it to Florence so we can spend a day and one night there if possible as it would shave 2 hours off the trip, so if that is reasonable suggestions on where to stay would also be helpful. I can check RS guidebook of course but if anyone has a fav place please do share if this makes sense. We current have 4 nights in Siena and 2 more south of Siena in Tuscany so extra time in the area but Florence was on our list to visit anyway.
We are trying to figure out the train routes and options to travel from Murren, Switzerland to Siena, Italy. We will be traveling on 9/15 which is a Monday. The options are limited to a longer train route - Mürren - Interlaken - Spiez - Brig - Domodossola - Milan - Florence - Siena which is 12-14 hours not arriving in Siena until 9:40PM . The late arrival makes me nervous especially with 5 transfers since we could miss a connection.
It looks like more options on the weekends for earlier arrival, but on Monday I do not see alternatives like fast trains?
We are wondering if anyone knows other options that may be more convenient. It also seems using a 4 day Erail pass may be the best option coastwise but again open to suggestions.